Fig. 5
Examples of drugs that are predicted to have high tumor-to-normal sensitivity for some tumor types. Violin plots of predicted IC50 values in tumor (red) and normal (blue) tissue for trametinib a sapitinib b and luminespib c that showed the ratio of tumor-to-normal sensitivity exceeding 2.7 (1 logarithmic unit) for at least one of 14 tissue types. The ln (IC50) values of the drugs were predicted based on the RNA-seq data of the tumor and normal tissue samples from TCGA. Violin plots for normal and tumor samples from the same tissue type are shown as side-by-side pairs with their TCGA type on the X-axis. See Fig. 2 legend for additional description of the violin plots. Red star (*) indicates the difference between the median of predicted IC50 values for normal samples and the median of predicted IC50 values for tumor samples is more than one logarithmic unit